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Seven patients with carcinomatous meningitis were administered intrathecal I-131 labelled monoclonal antibody HMFG1.Clinical responses were seen in two patients,with a long term survivor at 32 months.Aseptic meningitis occurred in 4/7 patients,but more serious toxicity was observed in the form of seizures(2/7 patients)and myelosuppression(3/7 patients).Partial obliteration of the subarachnoid space was identified as a potential problem in patients with advanced disease. |
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